The Africa Governance Monitoring and Advocacy Project (AfriMAP) monitors the compliance of member states of the African Union with selected standards of good governance, democracy, human rights, and the rule of law.

The Central Eurasia Project strives to enhance policy debate on key issues affecting Central Asia and the South Caucasus as well as several countries in the Middle East and North Africa.

The East East: Partnership Beyond Borders Program supports international exchanges that bring together civil society actors to share ideas, information, knowledge, experiences, and expertise and to support practical actions that result from that networking.

EUMAP (the EU Monitoring and Advocacy Program) monitors the development of selected human rights and rule of law issues in both the European Union and in its candidate and potential candidate countries.

The Global Drug Policy Program aims to engage and support drug policy experts and other related professionals as they analyze and publicize the effects of drug policy on public health, human rights, national security, and the economy.

The Human Rights and Governance Grants Program provides support to nongovernmental organizations operating in the fields of human rights and governance in Europe and Central Asia.

The Information Program promotes the equitable deployment of knowledge and communications resources for civic empowerment and effective democratic governance.

The Latin America Program works throughout the region to create more open societies, enhance human rights protections, and encourage the implementation of economic and political policies firmly rooted in democracy.

The Local Government & Public Service Reform Initiative promotes democratic and effective governance and public administration, and advances policy analysis as a tool for decision making in public affairs.

OSI's Middle East & North Africa Initiative operates primarily as a grantmaking program on issues ranging from media and information to women's rights.

The Open Society Fellowship enables innovative professionals—including journalists, activists, academics, and practitioners—to work on projects that inspire meaningful public debate, shape public policy, and generate intellectual ferment within the Open Society Institute.

The Open Society Justice Initiative, an operational program of the Open Society Institute, pursues law reform activities grounded in the protection of human rights, and contributes to the development of legal capacity for open societies worldwide.

OSI-Baltimore focuses on helping youth succeed, reducing the social and economic costs of incarceration, tackling drug addiction, and building a corps of Community Fellows to bring innovative ideas to Baltimore’s underserved communities.

OSI-Washington, D.C. focuses on civil liberties in the United States as well as other domestic and international policy issues, including globalization, criminal justice reform, human rights, and women's rights.

OSI's U.S. Programs aims to address core threats to open society, including increasingly punitive national security policies, decreasing government transparency, entrenched structural racism, and growing incarceration rates.