Since the Open Society Fund–Lithuania ended its grantmaking in 2006, OSI has administered a small legacy fund to support organizations focusing on civil society, the rule of law, democracy promotion, and citizen participation. In 2007, the Civil Society Institute in Vilnius was the primary beneficiary of this fund. The institute supported efforts to challenge social exclusion and promote public debate on political and social issues. Several OSI programs pursued partnerships and supported projects that addressed HIV and TB, sex worker issues, and women’s rights in Lithuania and the region.

The main objective of the Open Society Fund–Lithuania was to support the development of an open, democratic, and civil society in Lithuania. Its programs focused on issues of migration, labor and employment, education, science, public health, information technology development, communication and publishing, culture, civil society, democracy, law, access to justice and poverty reduction.

The fund gave given particular attention to the European Union (EU) accession process, working to increase public awareness of the challenges and responsibilities that come with political and economic reform and analyzing the impact of EU membership on Lithuania's foreign trade policies.